简介:Aquaporins (AQPs) are a large family of integral membrane water transport
channel proteins that facilitate the transport of water through the cell membrane.
This function is conserved in animals, plants and bacteria. M简介:Aquaporins (AQPs) are a large family of integral membrane water transport
channel proteins that facilitate the transport of water through the cell membrane.
This function is conserved in animals, plants and bacteria. Many isoforms
of aquaporin have been identified in mammals, designated AQP0
through AQP10. Aquaporins are widely distributed and it is not uncommon
for more than one type of AQP to be present in the same cell. Although most
aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the
two AQP10 transcripts are also permeable to urea and glycerol. Aquaporins
are involved in renal water absorption, generation of pulmonary secretions,
lacrimation, and the secretion and reabsorption of cerebrospinal fluid and
aqueous humor. Human AQP7 is a 342 amino acid protein that facilitates
water, glycerol and urea transport, and is predominately expressed in adipose
tissue.详细>