简介:Solid-Assisted Solution Phase Synthesis (SASPS) is a technique where the target molecule is
synthesized in solution and solid-supported molecules are used as reagents, catalysts or
scavengers. Recently this technique h简介:Solid-Assisted Solution Phase Synthesis (SASPS) is a technique where the target molecule is
synthesized in solution and solid-supported molecules are used as reagents, catalysts or
scavengers. Recently this technique has been getting a lot of attention as an alternative to solid
phase organic synthesis (SPOS), since it offers many of the advantages of SPOS in terms of ease of
reaction workup and product purification in addition to the advantages associated with traditional
solution-phase chemistry (e.g. the ease of monitoring the progress of the reaction by simply
applying LC-MS or TLC techniques). A disadvantage of this technique is the relative slow reaction
rate, and many of these reactions are sluggish and require hours for complete conversion. The
advent of Microwave-Assisted Organic Synthesis (MAOS) has helped accelerate these reactions and
the technique is gaining rapid popularity as evidenced by the increasing number of publications on
this topic. The polymer backbones are in general, stable at the high temperatures used with MAOS
for the short periods of time required for most of these reactions. This technique is particularly
well-suited for automation and can easily incorporate in-line purification protocols, such as reagent
and byproduct scavenging and catch-and-release. This introduces the possibility of direct highthroughput
synthesis of compounds with intrinsically high purities suitable for biological screening
without the need for further purification.详细>