简介:P-glycoprotein (P-gp/ABCB1) and breast cancer resistance
protein (BCRP/ABCG2) combination knockout mice display disproportionately
increased brain penetration of shared substrates, including topotecan and
several tyro简介:P-glycoprotein (P-gp/ABCB1) and breast cancer resistance
protein (BCRP/ABCG2) combination knockout mice display disproportionately
increased brain penetration of shared substrates, including topotecan and
several tyrosine kinase inhibitors, compared to mice deficient for only one
transporter. To better study the interplay of both transporters also in vitro, we
generated a transduced polarized MDCKII cell line stably coexpressing
substantial levels of human ABCB1 and ABCG2 (MDCKII-ABCB1/ABCG2).
Next, we measured concentration-dependent transepithelial transport详细>