简介:β-lactamases are either plasmid or chromosomally encoded bacterial enzymes which hydrolyze β-lactam antibiotics. The majority of β-lactamases produced by clinical isolates are serine active site enzymes. One successful a简介:β-lactamases are either plasmid or chromosomally encoded bacterial enzymes which hydrolyze β-lactam antibiotics. The majority of β-lactamases produced by clinical isolates are serine active site enzymes. One successful approach to combating the serine active site β-lactamases is the use of β-lactamase inhibitors,such as clavulanic acid, in combination with a β-lactam antibiotic4.详细>