简介:1. Why chirality analysis important
The analysis of chiral molecules is of central importance to modern day chemistry,
biochemistry [1] and material science [2-4]. Enantiomeric purity is as paramount as
chemical purit简介:1. Why chirality analysis important
The analysis of chiral molecules is of central importance to modern day chemistry,
biochemistry [1] and material science [2-4]. Enantiomeric purity is as paramount as
chemical purity to the pharmaceutical industry [5]. Related to this is the optical
purity of chiral catalysts and the resulting enantiomeric excess measurements
necessary to evaluate synthetic transformations. Analytical techniques capable of
surveying chirality have also been used to elucidate reaction mechanisms [1]. More
recently materials including polymers [6] as well as supramolecular assemblies and
switches [7-10] employing chiral elements have given rise to differential behavior
with matter and energy. These initial reports may pave the way for molecular
machines and data storage devices that use chirality. On a macromolecular scale,
discrete proteins, DNA, RNA, polysaccharides and complexes of these biomolecules
are routinely analyzed using chiral optical techniques to gain insight into their threedimensional
structural features, most notably their helicity [1].详细>