简介:In hemodynamics, the inherent intermittency of two-phase cellular-level flow has received little attention.
Unsteadiness is reported and quantified for the first-time in the literature using a combination of
fluorescen简介:In hemodynamics, the inherent intermittency of two-phase cellular-level flow has received little attention.
Unsteadiness is reported and quantified for the first-time in the literature using a combination of
fluorescent dye labelling, time-resolved scanning confocal microscopy, and micro-particle image
velocimetry (μPIV). The near-wall red blood cell (RBC) motion of physiologic high-hematocrit blood in
a rectangular microchannel was investigated under pressure driven flow. Intermittent flow was associated
with (1) the stretching of RBCs as they passed through RBC clusters with twisting motions; (2) external
flow through local obstacles; and (3) transitionary rouleaux formations. Velocity profiles are presented
for these cases. Unsteady flow clustered in local regions. Extra-cellular fluid flow generated by
individual RBCs was examined using submicron fluorescent microspheres. The capabilities of confocal
μPIV post-processing were verified using synthetic raw PIV data for validation. Cellular interactions and
oscillating velocity profiles are presented and 3D data are made available for computational model
validation.详细>