Analysis and Purification Methods in Combinatorial Chemistry(分离与纯化)
简介:CHAPTER 1 QUANTITATIVE ANALYSIS IN
ORGANIC SYNTHESIS WITH NMR
SPECTROSCOPY 3
Laura H. Lucas and Cynthia K. Larive
CHAPTER 2 19F GEL-PHASE NMR
SPECTROSCOPY FOR REACTION
MONITORING AND QUANTIFICATION
OF RESIN LOADIN简介:CHAPTER 1 QUANTITATIVE ANALYSIS IN
ORGANIC SYNTHESIS WITH NMR
SPECTROSCOPY 3
Laura H. Lucas and Cynthia K. Larive
CHAPTER 2 19F GEL-PHASE NMR
SPECTROSCOPY FOR REACTION
MONITORING AND QUANTIFICATION
OF RESIN LOADING 37
Joseph M. Salvino
CHAPTER 3 THE APPLICATION OF SINGLE-BEAD
FTIR AND COLOR TEST FOR REACTION
MONITORING AND BUILDING BLOCK
VALIDATION IN COMBINATORIAL
LIBRARY SYNTHESIS 53
Jason J. Cournoyer, Clinton A. Krueger, Janice V.Wade,
and Bing Yan
CHAPTER 4 HR-MAS NMR ANALYSIS OF
COMPOUNDS ATTACHED TO
POLYMER SUPPORTS 71
Meritxell Guinó and Yolanda R. de Miguel
v
CHAPTER 5 MULTIVARIATE TOOLS FOR REAL-TIME
MONITORING AND OPTIMIZATION OF
COMBINATORIAL MATERIALS AND
PROCESS CONDITIONS 87
Radislav A. Potyrailo, Ronald J. Wroczynski,
John P. Lemmon,William P. Flanagan,
and Oltea P. Siclovan
CHAPTER 6 MASS SPECTROMETRY AND SOLUBLE
POLYMERIC SUPPORT 125
Christine Enjalbal, Frederic Lamaty, Jean Martinez,
and Jean-Louis Aubagnac
PART II HIGH-THROUGHPUT ANALYSIS FOR LIBRARY
QUALITY CONTROL 137
CHAPTER 7 HIGH-THROUGHPUT NMR TECHNIQUES
FOR COMBINATORIAL CHEMICAL
LIBRARY ANALYSIS 139
Ting Hou and Daniel Raftery
CHAPTER 8 MICELLAR ELECTROKINETIC
CHROMATOGRAPHY AS A TOOL FOR
COMBINATORIAL CHEMISTRY ANALYSIS:
THEORY AND APPLICATIONS 175
Peter J. Simms
CHAPTER 9 CHARACTERIZATION OF SPLIT-POOL
ENCODED COMBINATORIAL
LIBRARIES 209
Jing Jim Zhang and William L. Fitch
PART III HIGH-THROUGHPUT PURIFICATION TO
IMPROVE LIBRARY QUALITY 253
CHAPTER 10 STRATEGIES AND METHODS FOR
PURIFYING ORGANIC COMPOUNDS
AND COMBINATORIAL LIBRARIES 255
Jiang Zhao, Lu Zhang, and Bing Yan
vi contents
CHAPTER 11 HIGH-THROUGHPUT PURIFICATION:
TRIAGE AND OPTIMIZATION 281
Jill Hochlowski
CHAPTER 12 PARALLEL HPLC IN HIGHTHROUGHPUT
ANALYSIS AND
PURIFICATION 307
Ralf God and Holger Gumm
PART IV ANALYSIS FOR COMPOUND STABILITY AND
DRUGABILITY 321
CHAPTER 13 ORGANIC COMPOUND STABILITY
IN LARGE, DIVERSE PHARMACEUTICAL
SCREENING COLLECTION 323
Kenneth L. Morand and Xueheng Cheng
CHAPTER 14 QUARTZ CRYSTAL MICROBALANCE IN
BIOMOLECULAR RECOGNITION 351
Ming-Chung Tseng, I-Nan Chang, and Yen-Ho Chu
CHAPTER 15 HIGH-THROUGHPUT PHYSICOCHEMICAL
PROFILING: POTENTIAL AND
LIMITATIONS 369
Bernard Faller
CHAPTER 16 SOLUBILITY IN THE DESIGN OF
COMBINATORIAL LIBRARIES 407
Christopher Lipinski
CHAPTER 17 HIGH-THROUGHPUT DETERMINATION
Jenny D. Villena, Ken Wlasichuk, Donald E. Schmidt Jr.,
and James J. Bao
INDEX 457详细>