Fabrication of pH sensitive amphiphilic hot-melt pressure sensitive adhesives for transdermal drug delivery system
简介:Based on the blend of styrene-isoprene-styrene (SIS) thermoplastic elastomer and acrylic resin Eudragits
EPO, amphiphilic hot-melt pressure sensitive adhesives (HMPSAs) were fabricated. Compatibility and
micromorphology 简介:Based on the blend of styrene-isoprene-styrene (SIS) thermoplastic elastomer and acrylic resin Eudragits
EPO, amphiphilic hot-melt pressure sensitive adhesives (HMPSAs) were fabricated. Compatibility and
micromorphology of SIS/EPO blends (SEBs) were analyzed with differential scanning calorimetry (DSC),
atomic force microscopy (AFM) and scanning electron microscopy (SEM). The results showed that when
the mass ratio of SIS to EPO was 1:1 1:2, bicontinuous structure was formed. Following the addition of
an appropriate amount of polyethylene glycol (PEG), mineral oil and C5 resin, the amphiphilic HMPSAs
were prepared. Because of the compatibility between SIS and EPO, as well as the hydrogen bond
interaction between EPO and PEG, amphiphilic HMPSAs showed good thermostability. The adhesive
performance of HMPSAs was measured with 1801 peeling strength and holding power. Geniposide and
oleanolic acid were used as model drugs to investigate drug release behavior. When the mass ratio of PEG
to SEB was 13:30 16:30, the HMPSAs could maintain good adhesion performance and achieve continual
release of both hydrophilic and lipophilic drugs. In weakly acidic conditions, the HMPSAs exhibited good
hygroscopicity and release profile, it was shown that pH sensitive amphiphilic HMPSAs were more
suitable for transdermal drug delivery system (TDDS).详细>