简介:联系人:侯先生 13691497252 Analysis of Narcotics and Narcotic / Acetaminophen Admixtures: What to do When Compendium Methods Don't Work At some point in their careers, especially if performing raw materials or generic t简介:联系人:侯先生 13691497252 Analysis of Narcotics and Narcotic / Acetaminophen Admixtures: What to do When Compendium Methods Don't Work At some point in their careers, especially if performing raw materials or generic testing analyses for pharmaceuticals, analytical chemists are referred to compendium methodologies, most often to the United States Pharmacopoeia (USP), the European Pharmacopoeia (EP), or the British Pharmacopoeia (BP), but occasionally to other volumes. Often the methods described in these compendia provide less than the desired robustness in separation and reproducibility, or the results may be marginal—barely passing system suitability requirements. Sometimes a particular delivery system formulation absolutely will not work with a generic method, due to interference from other ingredients in the sample. Modifications must be made to the problem methodology, and the results compared statistically to the original. To improve analysis efficiency and reduce laboratory supply costs associated with revalidating and testing a method, it may be desirable to create and validate a single analytical method for a wide range of similar drug products.
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