The vertical diffusion cell (VDC) system is a simple, reliable, and reproducible means of measuring drug release from semisolid (cream, ointment, and gel) dosage forms.
The membrane, with its application side up, is placed in a VDC (typically a 15-mm diameter orifice), e.g., a Franz cell. The VDC assembly consists of two chambers (a donor chamber and a receptor chamber), separated by a donor compartment and held together by a clamp.
This type of cell is commonly used for testing the in vitro release rate of topical drug products, cosmetics, skin-care products and ophthalmics.
USP 1724 compliant
Compatible Cells
Part No. | Descriptoin | OEM Ref |
PSVDC0904CP-HR | Clear Glass – Complete VDC cell Vertical Diffusion Cell, Clear Glass, 9 mm Orifice, 4 mL vol, “Small” | 58-001-451 |
PSVDC1507CP-HR | Vertical Diffusion Cell, Clear Glass, 15 mm Orifice, 7 mL vol, “Standard” Recommended by US FDA for topicals | 58-001-455 |
PSVDC1512CP-HR | Vertical Diffusion Cell, Clear Glass, 15 mm Orifice, 12 mL vol, “Large” | 58-001-459 |
PSVDC1520CP-HR | Vertical Diffusion Cell, Clear Glass, 15 mm Orifice, 20 mL vol, “Large” | – |
PSVDC0904CO-HR | Clear Glass – VDC cell Only Vertical Diffusion Cell, Clear Glass, 9 mm Orifice, 4 mL vol, “Small” | 58-001-453 |
PSVDC1507CO-HR | Vertical Diffusion Cell, Clear Glass, 15 mm Orifice, 7 mL vol, “Standard” Recommended by US FDA for topicals | 58-001-457 |
PSVDC1512CO-HR | Vertical Diffusion Cell, Clear Glass, 15 mm Orifice, 12 mL vol, “Large” | 58-001-461 |
PSVDC1520CO-HR | Vertical Diffusion Cell, Clear Glass, 15 mm Orifice, 20 mL vol, “Large” | – |
Part No. | Descriptoin | OEM Ref |
PSVDC0904CP-AHR | Amber Glass – Complete VDC cell Vertical Diffusion Cell, Amber Glass, 9 mm Orifice, 4 mL vol, “Small” | 58-001-452 |
PSVDC1507CP-AHR | Vertical Diffusion Cell, Amber Glass, 15 mm Orifice, 7 mL vol, “Standard” | 58-001-456 |
PSVDC1512CP-AHR | Vertical Diffusion Cell, Amber Glass, 15 mm Orifice, 12 mL vol, “Large” | 58-001-460 |
PSVDC1520CP-AHR | Vertical Diffusion Cell, Amber Glass, 15 mm Orifice, 20 mL vol, “Large” | – |
PSVDC0904CO-AHR | Amber Glass – VDC cell Only Vertical Diffusion Cell, Amber Glass, 9 mm Orifice, 4 mL vol, “Small” | 58-001-454 |
PSVDC1507CO-AHR | Vertical Diffusion Cell, Amber Glass, 15 mm Orifice, 7 mL vol, “Standard” | 58-001-458 |
PSVDC1512CO-AHR | Vertical Diffusion Cell, Amber Glass, 15 mm Orifice, 12 mL vol, “Large” | 58-001-462 |
PSVDC1520CO-AHR | Vertical Diffusion Cell, Amber Glass, 15 mm Orifice, 20 mL vol, “Large” | – |
VDC Parts
Part No. | Descriptoin | OEM Ref |
PSVDCGLDSK-HR | Glass Disk, suited for all TDS cells | 58-001-506 |
PSVDCCLRNG-HR | Cell ring | 58-001-507 |
PSVDCDSW09-HR | Dosage wafer for 4ml cells, 9 mm orifice | 58-001-518 |
PSVDCDSW15-HR | Dosage wafer for 7, 12, 20ml cells, 15 mm orifice | 58-001-511 |
PSVDCCLPAS-HR | Clamp Assembly for 4, 7, 12, 20ml cells | 58-001-450 |
PSVDC0904CT-HR | Threaded Cell Top, Clear Glass, 2ml volume suited for 4ml cell | 58-001-530 |
PSVDC1507CT-HR | Threaded Cell Top, Clear Glass, 6mll volume suited for 7, 12 and 20ml cell | 58-001-531 |
PSVDCMSP06-HR | Stirrer Plate 6-position | 58-001-420 |
PSVDCMC40-HR | Universal Speed control unit, 40 Watt, RS232 | 58-001-425 |
Permeation cell with isofill chamber was developed especially for automatic sampling, which can also pose a difficulty especially for the Franz Cell. Furthermore, this model can be used with labile skins such as separated epidermis or mucous membranes of all kinds. An additional problem for cells with horizontal application is the formation of air bubbles under the skin. Vertical application as well as the design of the permeation cell with isofill chamber can avoid this problem. Permeation area of the cell is approx. 65mm2.
Part No. | Descriptoin | OEM Ref |
PSKERSKI-01 | Permeation cell with isofill chamber for liquides, approx. 10ml | – |
PSKERSKI-02 | Permeation cell with isofill chamber for (semi)solid dosage forms, approx. 10 ml | – |
PSKERSKI-03 | Permeation cell with isofill chamber for (semi)solid dosage forms, approx. 5 ml | – |
PSKERSKI-04 | Permeation cell with isofill chamber for (semi)solid dosage forms, approx. 20 ml | |
PSVDCMSP15-HR | Magnetic Stirrer MixDrive 15 pos. | – |
PSVDCMC40-HR | Universal Speed control unit, 40 Watt, RS232 | – |
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