Accucore HILIC 色谱柱 17526-154630

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Accucore™ HILIC LC 色谱柱

Thermo Scientific Accucore HILIC LC 色谱柱可以为极性和亲水性分析物提供增强的保留能力。 基于 Core Enhanced Technology™ (增强核技术™)， Accucore 色谱柱可提供快速、高分离度的分离，而无需亚 2 μm 颗粒所需的高反压。

• 快速分离，具有出色的分辨率和灵敏度

• 反压更低，因此无需 UHPLC

• 对极性和亲水性分析物具有更高的保留能力

• 与 C18 具有不同的选择性，无需使用离子对或衍生化试剂

• 提高 MS 检测灵敏度

Accucore HILIC
* Enhanced retention of polar and hydrophilic analytes
* Alternative selectivity to C18 without ion-pair or derivatization

In HILIC mode the separation occurs through two mechanisms. The primary mechanism is a partitioning effect due to the enriched water layer around the polar or charged substrate material. The secondary mechanism involves interaction between the analyte and the active surface moiety.
Analyte properties that govern retention with HILIC phases are acidity/basicity, which determines hydrogen bonding, and polarizability which determines dipole-dipole interactions.
The highly organic mobile phases used with Accucore HILIC phase ensure efficient desolvation in ESI MS detection, which in turn leads to improved sensitivity.

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