氧化还原因子1抗体

氧化还原因子1抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

氧化还原因子1抗体产品介绍

    转录调节因子（Transcriptin Regulators）
    APEX(Ref-1)是一种多功能蛋白,除了修复AP位点外,还保持很多转录因子包括AP-1、NF-κB、CREB、ATF、myb、Pax、HIF-1α、HLF、Egr-1、NF-Y、p53和PEBP2等活性还原状态,对维持DNA的稳定和调节细胞因子的表达具有重要作用.
    APE1是一种具有DNA修复、氧化还原以及调节转录因子活性的多功能蛋白, APE在多种细胞抗氧化损伤过程中起重要的作用。
    Ref-1在体内是一种广泛表达的基因,胞质、胞核及胞质和胞核同时表达三种表达模式,与细胞的分化成熟过程有关.APE/Ref-1蛋白的不正常表达、分布及功能改变与细胞凋亡、肿瘤发生、神经系统退行性疾病和老年化等病理过程密切相关. 
    Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

Alternate Names: 
AP endonuclease 1;
AP endonuclease class I; 
AP lyase; 
APE 1 ;
APE; 
APEN ;
APEX 1 
; APEX; 
APEX nuclease (multifunctional DNA repair enzyme) 1;
Apex nuclease 1; 
Apex nuclease; 
APEX1; 
Apurinic/apyrimidinic (abasic) endonuclease;
Apurinic/apyrimidinic exonuclease; 
APX ; 
Deoxyribonuclease (apurinic or apyrimidinic) ; 
DNA (apurinic or apyrimidinic site) lyase; 
HAP 1; HAP1; 
Multifunctional DNA repair enzyme;
Redox factor 1; 
REF 1; 
REF 1 protein ; 
REF1; 
REF1 protein

氧化还原因子1抗体

hz-0358D-AF488 Donkey Anti-Guinea pig IgG/Alexa Fluor 488  Alexa Fluor 488标记的驴抗豚鼠IgG

hz-0358D-AF555 Donkey Anti-Guinea pig IgG/Alexa Fluor 555  Alexa Fluor 555标记的驴抗豚鼠IgG

hz-0358D-AF647 Donkey Anti-Guinea pig IgG/Alexa Fluor 647  Alexa Fluor 647标记的驴抗豚鼠IgG

hz-0358D-PE-hzy5.5 Donkey Anti-Guinea pig IgG/PE-Cy5.5  PE-Cy5.5标记的驴抗豚鼠IgG

hz-0358D-PE-hzy7 Donkey Anti-Guinea pig IgG/PE-Cy7  PE-Cy7标记的驴抗豚鼠IgG

hz-0358D-FIThz Donkey Anti-Guinea pig IgG/FITC  FITC标记的驴抗豚鼠IgG

hz-0358D-RBIThz Donkey Anti-Guinea pig IgG/RBITC  罗丹明标记的驴抗豚鼠IgG

hzm-0297M-RBIThz Mouse Anti-human IgG(3D3)/RBITC  罗丹明标记的鼠抗人IgG单克隆抗体

hzm-0297M-FIThz Mouse Anti-human IgG(3D3)/FITC  FITC标记的鼠抗人IgG单克隆抗体

hzm-0297M-Gold Mouse Anti-human IgG(3D3)/Gold  胶体金标记的鼠抗人IgG单克隆抗体

hzm-0297M-hzy3 Mouse Anti-human IgG(3D3)/Cy3  Cy3标记的鼠抗人IgG单克隆抗体

hzm-0297M-hzy5 Mouse Anti-human IgG(3D3)/Cy5  Cy5标记的鼠抗人IgG单克隆抗体

hzm-0297M-hzy5.5 Mouse Anti-human IgG(3D3)/Cy5.5  Cy5.5标记的鼠抗人IgG单克隆抗体

hzm-0297M-hzy7 Mouse Anti-human IgG(3D3)/Cy7  Cy7标记的鼠抗人IgG单克隆抗体

hzm-0297M-PE Mouse Anti-human IgG(3D3)/PE  PE标记的鼠抗人IgG单克隆抗体

hzm-0297M-PE-hzy3 Mouse Anti-human IgG(3D3)/PE-Cy3  PE-Cy3标记的鼠抗人IgG单克隆抗体

hzm-0297M-PE-hzY5 Mouse Anti-human IgG(3D3)/PE-CY5  PE-CY5标记的鼠抗人IgG单克隆抗体

hzm-0297M-APhz Mouse Anti-human IgG(3D3)/APC  APC标记的鼠抗人IgG单克隆抗体

hzm-0297M-AF350 Mouse Anti-human IgG(3D3)/Alexa Fluor 350  Alexa Fluor 350标记的鼠抗人IgG单克隆抗体

hzm-0297M-AF488 Mouse Anti-human IgG(3D3)/Alexa Fluor 488  Alexa Fluor 488标记的鼠抗人IgG单克隆抗体

hzm-0297M-AF555 Mouse Anti-human IgG(3D3)/Alexa Fluor 555  Alexa Fluor 555标记的鼠抗人IgG单克隆抗体

hzm-0297M-AF647 Mouse Anti-human IgG(3D3)/Alexa Fluor 647  Alexa Fluor 647标记的鼠抗人IgG单克隆抗体

hzm-0297M-PE-hzy5.5 Mouse Anti-human IgG(3D3)/PE-Cy5.5  PE-Cy5.5标记的鼠抗人IgG单克隆抗体

hzm-0297M-PE-hzy7 Mouse Anti-human IgG(3D3)/PE-Cy7  PE-Cy7标记的鼠抗人IgG单克隆抗体

hzm-0297M-HRP Mouse Anti-human IgG(3D3)/HRP  辣根过氧化物酶标记的鼠抗人IgG单克隆抗体

hzm-0297M-AP Mouse Anti-human IgG(3D3)/AP  碱性磷酸酶（AP）标记的鼠抗人IgG单克隆抗体

hzm-0297M-Bio Mouse Anti-human IgG(3D3)/Bio  生物素标记的鼠抗人IgG单克隆抗体

五、蛋白质与多肽

编  号 名  称

hz-0292P BSA (bovine serum albumin)  牛血清白蛋白（第五组分）

hz-0225P KLH (keyhole limpet hhzocyanin)  血蓝蛋白

hz-0283P OVA (ovalbumin)  鸡卵白蛋白

hz-0291P THY (thyroglobulin,TG)  甲状腺球蛋白

hz-0945P HSA/human Serum albumin  人血清白蛋白