英文名称 FUSIP1
中文名称 富含丝氨酸/精氨酸重复结构蛋白抗体
别 名 40 kDa SR repressor protein; 40 kDa SR-repressor protein; Anti TLS associated protein with SR repeats; arginine/serine-rich 13A; FUS interacting protein serine arginine rich 1; FUS interacting protein serine arginine rich 2; FUS interacting serine arginine rich protein 1; FUS-interacting serine-arginine-rich protein 1; FUSIP1; FUSIP2; NSSR; OTTHUMP00000015774; Serine arginine repressor protein 40 kDa; Serine/arginine-rich splicing factor 10; SFRS13; SFRS13A; Splicing factor; Splicing factor arginine serine rich 13; Splicing factor SRp38; SRp38; SRp40; SRrp40; SRS10_HUMAN; Srsf10; TASR; TASR1; TASR2; TLS associated protein TASR1; TLS associated protein TASR2; TLS associated protein with Ser Arg repeats; TLS associated protein with SR repeats; TLS associated serine arginine protein 1; TLS associated serine arginine protein 2; TLS associated serine arginine protein; TLS associated SR protein; TLS-associated protein with Ser-Arg repeats; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated SR protein.
说 明 书 0.2ml
研究领域 神经生物学 细胞周期蛋白 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 富含丝氨酸/精氨酸重复结构蛋白抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human FUSIP1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
富含丝氨酸/精氨酸重复结构蛋白抗体产品介绍 background:
FUSIP1 is a member of the Serine/Arginine (SR) family of splicing factors. Members of the SR family all contain one or more RNA recognition motifs (RRM) and an SR-rich domain. SR factors are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. Expressed in a variety of tissues with low expression in kidney, liver and heart, FUSIP1 localizes to the cytoplasm and nuclear speckles. In its dephosphorylated form (occurring during M phase of the cell cycle), FUSIP1 functions as a potent general repressor of pre-mRNA splicing and can interact with U1 SnRNP 70. In its phosphorylated form, FUSIP1 interacts with Tra-2∫ and, together, they may cooperate in the regulation of splicing. Four isoforms exist for FUSIP1. In neurons, FUSIP1 isoforms may act to either positively or negatively regulate alternative splicing.
Function:
Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
Subunit:
The phosphorylated but not the dephosphorylated form interacts with TRA2B/SFRS10. The dephosphorylated form interacts with SNRNP70. Isoform 1 and isoform 3 interact with FUS C-terminus.
Subcellular Location:
Nucleus speckle. Cytoplasm.
Tissue Specificity:
Widely expressed.
Post-translational modifications:
Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock.
Isoform 3 is phosphorylated on Ser-168.
Similarity:
Belongs to the splicing factor SR family.
Contains 1 RRM (RNA recognition motif) domain.
Database links:
UniProtKB/Swiss-Prot: O75494.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
富含丝氨酸/精氨酸重复结构蛋白抗体
hz-0552P Collagen V (Anti--Collagen Type V ) Ⅴ型胶原(多肽)
hz-1428P CLDN1(Claudin 1) 紧密连接蛋白1抗原
hz-2183P Claudin-11 peptide 少突胶质细胞跨膜蛋白抗原
hz-0790P CLDN1(Claudin 1)C-term 紧密连接蛋白1抗原(C端)
hz-0582P COX-1 (Prostaglandin-endoperoxide synthase-1) 前列腺素氧化环化酶1抗原
hz-2047P CPT1A peptide 肉毒碱棕榈酰基转移酶1A多肽抗原
hz-1790P CRMP2/Dpysl2(collapsin response mediator protein-2) 二氢嘧啶酶样2CRMP2抗原
hz-1860P CRLR/CALCRL(calcitonin receptor like precursor) 降钙素受体样蛋白抗原
hz-1703P cRaf/Raf1(c-raf 1) cRaf/Raf1抗原
hz-1433P MEK1/MAPKK1(mitogen activated protein kinase kinase 1) MEK1/MAPKK1抗体(N-端)
hz-0382P CRF (Corticotropin-Releasing Factor) 促肾上腺皮质激素释放因子
hz-0793P CSIG(cellular senescence inhibited gene) 细胞衰老抑制基因抗原
hz-1566P Cripto-1(N-Terminus) 畸胎瘤衍化生长因子抗原(表皮生长因子相关肽)N端
hz-2141P Cripto-1(C-Terminus) 畸胎瘤衍化生长因子抗原(表皮生长因子相关肽)C端
hz-0848P Anti-CSP (circumsporozoite protein/Plasmodium yoelii) 环子孢子蛋白(约氏疟原虫)抗原
hz-2174P Calcitonin 降钙素抗原
hz-1410P CTBP1(C-terminal binding protein 1) C端结合蛋白1抗原
hz-1179P CTLA-4/CD152 淋巴细胞相关抗原4/细胞毒性T细胞抗原-4
hz-0799P CTn1 (cardiac troponin 1) 心肌肌钙蛋白
hz-1376P Cx32(Connexin-32) 间隙连接蛋白32抗原
hz-1266P CX36 (Connexin-36) 间隙连接蛋白36抗原
hz-1050P Cx40 (Connexin-40) 间隙连接蛋白40(多肽)
hz-0811P cx3cl1(chhzokine (C-X3-C motif) ligand 1) 趋化因子(C-X3-C 基元)配体1抗原
hz-1728P CX3CR1(CX3C-chhzokine receptor 1) CX3C趋化因子受体1抗原
hz-0571P Cyclin A 周期素A抗原
hz-0572P Cyclin B1 周期素B1抗原
hz-1148P Cyclin D2 周期素D2抗原
hz-0660P Cyclin D3(C-term) 周期素D3抗原
hz-1742P CYP3A4(Cytochrome p450 3A4) 细胞色素P450 3A4抗原
hz-1290P Cyr61/IGFBP10/CCN1(cysteine rich 61) 富半胱氨酸肝素结合蛋白61抗原
hz-0896P HCMV UL23/HHV5 UL23(Human Cytomegalovirus UL23 Gene) 人巨细胞病毒UL23抗原
hz-1007P DAD1 (dopamine D1 receptor) 多巴胺受体-D1抗原
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