叉头蛋白H1抗体

英文名称    FOXH1    

中文名称    叉头蛋白H1抗体    

别    名    FAST 1; Fast 2; Fast-1; Fast-2; FAST1; Fast2; Forkhead activin signal transducer 1; Forkhead activin signal transducer 2; Forkhead box H1; Forkhead box protein H1; FOX H1; FOXH 1; FOXH1; FOXH1_HUMAN; hFAST 1; hFAST-1; hFAST1; Human homolog of Xenopus forkhead activin signal transducer 1; TGF beta/Activin signal transducer FAST1.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  发育生物学  信号转导  转录调节因子  细胞分化  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 叉头蛋白H1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    39kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human FOXH1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.    

叉头蛋白H1抗体产品介绍    background:

Xenopus winged-helix factor, xFAST-1 (forkhead activin signal transducer-1) is a transcription factor that forms a complex with the receptor-regulated Smad protein, Smad2, and directly binds to activin response elements on DNA (1,2). The human homolog FAST-1 and the corresponding mouse homolog, designated FAST-2, share significant sequence homology with xFAST-1, including a conserved N-terminal forkhead domain that consists of 110 amino acid residues and is essential for binding DNA and regulating transcription in embryogenesis, in tumorigenesis and in the maintenance of differentiated cell states (3,4). FAST-1 and FAST-2 also contain a distinct C-terminal Smad interaction domain that is required for the association with various Smad proteins, including Smad2, Smad3 and Smad4 (3,5). Expression of FAST-1 and FAST-2 is predominantly observed during early development, with lower levels detected in adult tissues (6,7). FAST-1 and FAST-2 mediated DNA binding is attenuated by both TFG?and activin, indicating that these FAST proteins mediate TFG?induced signal transduction (3).

Function:
Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).

Subunit:
Interacts with the MH2 domains of SMAD2 and SMAD3. 

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous.

Similarity:
Contains 1 fork-head DNA-binding domain.

Database links:
UniProtKB/Swiss-Prot: O75593.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

叉头蛋白H1抗体

hz-0336R-FIThz Rabbit Anti-Monkey IgM/FITC  FITC标记的兔抗猴IgM

hz-0336R-RBIThz Rabbit Anti-Monkey IgM/RBITC  罗丹明标记的兔抗猴IgM

hz-0296R-RBIThz Rabbit Anti-mouse IgG/RBITC  罗丹明标记的兔抗小鼠IgG

hz-0296R-FIThz Rabbit Anti-mouse IgG/FITC  FITC标记的兔抗小鼠IgG

hz-0296R-Gold Rabbit Anti-mouse IgG/Gold  胶体金标记的兔抗小鼠IgG

hz-0296R-HRP Rabbit Anti-mouse IgG/HRP  辣根过氧化物酶标记的兔抗小鼠IgG

hz-0296R-AP Rabbit Anti-mouse IgG/AP  碱性磷酸酶（AP）标记的兔抗小鼠IgG

hz-0296R-Bio Rabbit Anti-mouse IgG/Bio  生物素标记的兔抗小鼠IgG

hz-0296R-hzy3 Rabbit Anti-mouse IgG/Cy3  Cy3标记的兔抗小鼠IgG

hz-0296R-hzy5.5 Rabbit Anti-mouse IgG/Cy5.5  Cy5.5标记的兔抗小鼠IgG

hz-0296R-hzy7 Rabbit Anti-mouse IgG/Cy7  Cy7标记的兔抗小鼠IgG

hz-0296R-PE Rabbit Anti-mouse IgG/PE  PE标记的兔抗小鼠IgG

hz-0296R-PE-hzy3 Rabbit Anti-mouse IgG/PE-Cy3  PE-Cy3标记的兔抗小鼠IgG

hz-0296R-PE-hzY5 Rabbit Anti-mouse IgG/PE-CY5  PE-CY5标记的兔抗小鼠IgG

hz-0296R-APhz Rabbit Anti-mouse IgG/APC  APC标记的兔抗小鼠IgG

hz-0296R-AF350 Rabbit Anti-mouse IgG/Alexa Fluor 350  Alexa Fluor 350标记的兔抗小鼠IgG

hz-0296R-AF488 Rabbit Anti-mouse IgG/Alexa Fluor 488  Alexa Fluor 488标记的兔抗小鼠IgG

hz-0296R-AF555 Rabbit Anti-mouse IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗小鼠IgG

hz-0296R-AF647 Rabbit Anti-mouse IgG/Alexa Fluor 647  Alexa Fluor 647标记的兔抗小鼠IgG

hz-0296R-PE-hzy5.5 Rabbit Anti-mouse IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗小鼠IgG

hz-0296R-PE-hzy7 Rabbit Anti-mouse IgG/PE-Cy7  PE-Cy7标记的兔抗小鼠IgG

hz-0368R-Bio Rabbit Anti-mouse IgM/Bio  生物素标记的兔抗小鼠IgM

hz-0368R-HRP Rabbit Anti-mouse IgM/HRP  辣根过氧化物酶标记的兔抗小鼠IgM

hz-0368R-Gold Rabbit Anti-mouse IgM/Gold  胶体金标记的兔抗小鼠IgM

hz-0368R-AP Rabbit Anti-mouse IgM/AP  碱性磷酸酶（AP）标记的兔抗小鼠IgM

hz-0368R-hzy5 Rabbit Anti-mouse IgM/Cy5  Cy5标记的兔抗小鼠IgM

hz-0368R-hzy5.5 Rabbit Anti-mouse IgM/Cy5.5  Cy5.5标记的兔抗小鼠IgM

hz-0368R-hzy7 Rabbit Anti-mouse IgM/Cy7  Cy7标记的兔抗小鼠IgM

hz-0368R-PE Rabbit Anti-mouse IgM/PE  PE标记的兔抗小鼠IgM

hz-0368R-PE-hzy3 Rabbit Anti-mouse IgM/PE-Cy3  PE-Cy3标记的兔抗小鼠IgM

hz-0368R-PE-hzY5 Rabbit Anti-mouse IgM/PE-CY5  PE-CY5标记的兔抗小鼠IgM

hz-0368R-APhz Rabbit Anti-mouse IgM/APC  APC标记的兔抗小鼠IgM