促卵泡刺激素受体抗体

英文名称    FSH receptor    

中文名称    促卵泡刺激素受体抗体    

别    名    Follicle-stimulating hormone receptor precursor; Follicle stimulating hormone receptor; Follicle stimulating hormone receptor isoform 1; Follitropin receptor; FSH receptor; FSHRO; LGR1; ODG1.    

说 明 书    0.1ml  0.2ml      

研究领域    神经生物学  信号转导      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 促卵泡刺激素受体抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    78kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human FSHR 225-270aa    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

促卵泡刺激素受体抗体产品介绍    background:

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Function:
Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Subunit:
Interacts with ARRB2.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Sertoli cells and ovarian granulosa cells.

DISEASE:
Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.

Similarity:
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.

Gene ID:
2492    

促卵泡刺激素受体抗体

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hz-2179P-hzy3 AACT/Cy3  荧光素Cy3标记胰糜蛋白酶

hz-0294P-A555 Goat IgG/Alexa Fluor 555  Alexa Fluor 555标记羊IgG(细胞流式同型对照)

hz-0293P-A555 Rat IgG/Alexa Fluor 555  Alexa Fluor 555标记大鼠IgG(细胞流式同型对照)

hz-0292P-hzy5 BSA/Cy5  荧光素Cy5标记牛血清白蛋白

hze-0311P Biotin/HRP  辣根过氧化物酶标记生物素

hze-0312P Avidin/HRP  辣根过氧化物酶标记亲合素

hze-0360G Goat Anti-human IgA/HRP  辣根过氧化物酶标记羊抗人IgA

hze-0302R Rabbit Anti-HRP/HRP  辣根过氧化物酶标记兔抗HRP

hze-0360R Rabbit Anti-human IgA/HRP  辣根过氧化物酶标记兔抗人IgA

hze-0437P Streptavidin/HRP  辣根过氧化物酶标记链霉亲和素

hze-0362P Protein A/HRP  辣根过氧化物酶标记的蛋白A

hze-0292P BSA/HRP   辣根过氧化物酶标记牛血清白蛋白

hze-0361P rec Protein G/HRP  辣根过氧化物酶标记的重组蛋白G

hz-0855P-HRP Insulin/HRP  辣根过氧化物酶标记人胰岛素蛋白

hz-0311P-AP Biotin/AP  碱性磷酸酶标记生物素

hz-0312P-AP Avidin/AP  碱性磷酸酶标记亲合素

hz-0437P-AP Streptavidin/AP  碱性磷酸酶标记链霉亲和素

hz-0360G-AP Goat Anti-human IgA/AP  碱性磷酸酶标记羊抗人IgA

hz-0360R-AP Rabbit Anti-human IgA/AP  碱性磷酸酶标记兔抗人IgA

hz-0362P-AP Protein A/AP  碱性磷酸酶标记的蛋白A

hz-0292P-AP BSA/AP  碱性磷酸酶标记标记牛血清白蛋白

hz-0361P-AP rec Protein G/AP  碱性磷酸酶标记的重组蛋白G

hzb-0360G Goat Anti-human IgA/Biotin  生物素化羊抗人IgA

hza-0297R Rabbit Anti-human IgG/Streptavidin  链霉亲和素标记兔抗人IgG

hzb-0295P Rabbit IgG/Biotin  生物素化兔IgG

hzb-0297P human IgG/Biotin  生物素化人IgG

hzb-0296P mouse IgG/Biotin  生物素化小鼠IgG

hzF-0292P BSA/FITC  荧光素标记牛血清白蛋白

hzF-0366R Rb Anti-FITC/FITC  荧光素标记兔抗FITC

hzF-0360G Goat Anti-human IgA/FITC  荧光素标记羊抗人IgA