弹性蛋白微原纤维界面因子2抗体

英文名称    EMILIN2    

中文名称    弹性蛋白微原纤维界面因子2抗体    

别    名    Elastin microfibril interface-located protein 2; Elastin microfibril interfacer 2; EMIL2_HUMAN; EMILIN-2; EMILIN2; extracellular glycoprotein EMILIN-2; FOAP-10; Protein FOAP-10.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  发育生物学  信号转导  糖蛋白  细胞外基质      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 弹性蛋白微原纤维界面因子2抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    112kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human EMILIN2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

弹性蛋白微原纤维界面因子2抗体产品介绍    background:

EMILINs (elastin microfibril interface located proteins) are extracellular matrix glycoproteins that localize to sites with proximity to elastin and microfibrils. They consist of an N-terminal cysteine rich EMI domain and a conserved C-terminal gC1q-like domain. EMILIN-1 is abundant in elastin-rich tissues such as blood vessels, skin, heart and lung. It influences placenta formation and initial organogenesis with a later role in interstitial connective tissue. EMILIN-2 is larger than EMILIN-1 and contains a unique proline-rich domain. It is likely involved in the process of elastogenesis. Multimerin-2 (also known as EMILIN-3 or EndoGlyx-1) is expressed during embryonic development. Multimerin-1 (also known as EMILIN-4) is expressed in platelets and the endothelium of blood vessels and may act as a carrier protein for platelet factor V. EMILIN-5 is encoded by the EMILIN3 gene and is sometimes referred to as EMILIN-3. It contains the N-terminal cysteine rich EMI domain but lacks the C-terminal gC1q-like domain. EMILIN-5 is expressed in human mesenchymal stem cells and plays an important role in skeletal development.

Function:
May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.

Subcellular Location:
Secreted > extracellular space > extracellular matrix. Found mainly at the interface between amorphous elastin and microfibrils.

Tissue Specificity:
Highest levels are present in fetal heart and adult lung. Intermediate levels in peripheral leukocytes, placenta, and spinal cord and low expression in fetal brain, spleen, thymus, and lung and in adult heart, aorta, testis, bone marrow, small intestine, thymus, lymph node, and appendix.

Similarity:
Contains 1 C1q domain.
Contains 1 collagen-like domain.
Contains 1 EMI domain.

Gene ID:
84034

Database links:

Entrez Gene: 84034 Human

SwissProt: Q9BXX0 Human

Unigene: 532815 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

弹性蛋白微原纤维界面因子2抗体

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