二氢乳清酸脱氢酶抗体

英文名称    DHODH    

中文名称    二氢乳清酸脱氢酶抗体    

别    名    DHOdehase; Dhodh; Dihydroorotate dehydrogenase (quinone); Dihydroorotate dehydrogenase; Dihydroorotate dehydrogenase mitochondrial; Dihydroorotate oxidase; Human complement of yeast URA1; mitochondrial; PYRD_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  信号转导  细胞骨架      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 二氢乳清酸脱氢酶抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    43kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DHODH    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

二氢乳清酸脱氢酶抗体产品介绍    background:

The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]

Function:
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Subcellular Location:
Mitochondrion inner membrane.

Post-translational modifications:
The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration.

DISEASE:
Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.

Similarity:
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Gene ID:
1723

Database links:

Entrez Gene: 1723 Human

Entrez Gene: 533873 Cow

Entrez Gene: 610755 Dog

Entrez Gene: 56749 Mouse

Entrez Gene: 65156 Rat

Entrez Gene: 494065 Zebrafish

Omim: 126064 Human

SwissProt: Q02127 Human

SwissProt: O35435 Mouse

SwissProt: Q63707 Rat

Unigene: 654427 Human

Unigene: 23894 Mouse

Unigene: 81502 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

二氢乳清酸脱氢酶抗体

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