英文名称 DCXR
中文名称 羰基还原酶2抗体
别 名 Carbonyl reductase 2; Carbonyl reductase II; DCR; Dcxr; DCXR_HUMAN; Dicarbonyl L xylulose reductase; Dicarbonyl/ L xylulose reductase; Dicarbonyl/L-xylulose reductase; HCR2; HCRII; Human carbonyl reductase 2; kiDCR; Kidney dicarbonyl reductase; L xylulose reductase; L-xylulose reductase; P34H; SDR20C1; Short chain dehydrogenase/reductase family 20C member 1; Sperm surface protein P34H; XR.
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 信号转导 新陈代谢
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 羰基还原酶2抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DCXR
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
羰基还原酶2抗体产品介绍 background:
DCXR is a 244 amino acid member of the short-chain dehydrogenases/reductases family. This peripheral membrane protein catalyzes NADPH-dependent reduction of mulitple sugars, including L-xylulose, to the osmolyte xylitol. Producing xylitol in the renal tubules can prevent osmotic stress. L-xylulose reductase functions as a homotetramer and is expressed highly in kidney, liver and epididymis. Essential pentosuria is the result of a partial deficiency of L-xylulose reductase. Red blood cells of normal individuals contain two L-xylulose reductases: a major and a minor isozyme. Red cells from patients with pentosuria contain only one isozyme. Due to its role in the uronate cycle of glucose metabolism, L-xylulose reductase has been implicated in the management of the long term complications of diabetes.
Function:
Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Subcellular Location:
Membrane. Probably recruited to membranes via an interaction with phosphatidylinositol.
Tissue Specificity:
Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.
DISEASE:
Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose.
Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
羰基还原酶2抗体
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