英文名称 DFFB
中文名称 DNA断裂因子抗体(蛋白酶激活脱氧核糖核酸酶)
别 名 CAD; Caldesmon; Caspase activated deoxyribonuclease; Caspase activated DNase; Caspase activated nuclease; CDM; CPAN; Deoxyribonuclease III, caspase activated; DFF 40; DFF2; DFF40; Didff; DNA fragmentation factor 40 kDa subunit; DNA fragmentation factor subunit beta; DNA fragmentation factor, 40 Da, beta polypeptide (caspase activated DNase); DNA fragmentation factor, 40 kD beta subunit; DNA fragmentation factor, 40 kD, beta polypeptide; DNA fragmentation factor, 40kDa, beta polypeptide (caspase activated DNase); DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); DNAation factor, beta subunit; DFFB_HUMAN.
说 明 书 0.2ml
研究领域 细胞生物 细胞凋亡 细胞周期蛋白 激酶和磷酸酶 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 DNA断裂因子抗体(蛋白酶激活脱氧核糖核酸酶)(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DFFB
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DNA断裂因子抗体(蛋白酶激活脱氧核糖核酸酶)产品介绍 background:
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008].
Function:
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Subunit:
Heterodimer of DFFA and DFFB. Interacts with HIST1H1A.
Subcellular Location:
Cytoplasm. Nucleus.
Similarity:
Contains 1 CIDE-N domain.
DNA断裂因子抗体(蛋白酶激活脱氧核糖核酸酶)
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hz-5914R CA III/Carbonic anhydrase 3 碳酸酐酶3抗体
hz-0332R factor VIII(FVIII) human 第八因子相关抗原抗体
hz-0434R factor VIII(FVIII) 第八因子相关抗原抗体
hz-5921R YBX-1/YB1 核酸敏感元件结合蛋白1
hz-1587R factor XIII 凝血因子13抗体(纤维蛋白稳定因子)
hz-0511R FADD Fas死亡结构域相关蛋白
hz-5922R PGRMC 孕激素受体膜相关元件抗体
hz-1349R phospho-FADD(Ser194) 磷酸化Fas死亡结构域相关蛋白抗体
hz-5699R phospho-FADD(Ser194) 磷酸化Fas死亡结构域相关蛋白抗体
hz-5060R FADS1 脂肪酸去饱和酶1抗体
hz-1340R FAK/PTK2 粘着斑激酶抗体
hz-3159R Phospho-FAK/PTK2(Tyr397) 磷酸化粘着斑激酶抗体
hz-3160R Phospho-FAK(Tyr861) 磷酸化粘着斑激酶抗体
hz-3162R Phospho-FAK(Tyr576/577) 磷酸化粘着斑激酶抗体
hz-3163R Phospho-FAK(Tyr925) 磷酸化粘着斑激酶抗体
hz-3164R Phospho-FAK(Tyr407) 磷酸化粘着斑激酶抗体
hz-1639R phospho-FAK(Tyr577) 磷酸化粘着斑激酶抗体
hz-5539R phospho-FAK(Ser722) 磷酸化粘着斑激酶抗体
hz-5540R phospho-FAK(Tyr925) 磷酸化粘着斑激酶抗体
hz-1348R FAF1 Fas相关1因子抗体
hz-1642R phospho-FAK(Ser732) 磷酸化粘着斑激酶抗体
hz-3357R FAK2/PYK2 富含脯氨酸的酪氨酸激酶2抗体
hz-3400R phospho-Pyk2/PTK2B(Tyr402) 磷酸化富含脯氨酸的酪氨酸激酶2抗体
hz-3401R phospho-Pyk2 (Tyr881) 磷酸化富含脯氨酸的酪氨酸激酶2抗体
hz-5061R FAR2 脂肪酰辅酶A还原酶2抗体
hz-5541R phospho-PTK2(Tyr576+Tyr577) 磷酸化粘着斑激酶抗体
hz-2738R FANCD2 FANCD2抗体
hz-3015R phospho-FANCD2(Ser222) 磷酸化FANCD2抗体
hz-1580R FANCF 范可尼贫血相关蛋白F抗体
hz-0711R FAM3B/PANDER 胰腺衍生因子抗体
hz-5924R IMPDH2 5'肌苷磷酸脱氢酶2抗体
hz-0215R FAS/Apo-1/CD95 载脂蛋白A1抗体
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