英文名称 CATSPERB
中文名称 阳离子通道精子相关蛋白β亚基抗体
别 名 C14orf161; Cation channel sperm-associated protein subunit beta; Cation channel, sperm-associated, beta; Catsper channel auxiliary subunit beta; CatSper(beta); CATSPERB; FLJ14298; CTSRB_HUMAN.
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 免疫学 发育生物学 干细胞 转录调节因子 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 阳离子通道精子相关蛋白β亚基抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 127kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CATSPERB
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
阳离子通道精子相关蛋白β亚基抗体产品介绍 background:
CatSpers are ion transport proteins located on the surface of sperm cells in the principal piece of the sperm tail. CatSpers are vital to sperm motility, fertilization and cAMP-mediated calcium influx in sperm. There are four CatSper proteins in mammalian sperm, namely CatSper (or CatSper1), CatSper2, CatSper3 and CatSper4. CatSper proteins are believed to assemble into a heterotetrameric complex, forming an alkalinization-activated Ca2+-selective channel. CatSper∫ is a multipass membrane protein that functions as an auxiliary protein of the CatSper channel. It contains a large extracellular domain and a number of N-glycosylation sites. CatSper∫ specifically interacts with CatSper1 and through this interaction plays an important role in the hyperactivated motility of sperm cells, a process that is required in the preparation of sperm for fertilization.
Function:
RelevanceCATSPERB is a component of a complex composed at least of CATSPER1, CATSPERB, CATSPERG and HSPA1B. CATSPERB contains at least 2 transmembrane domains and 8 N-glycosylation sites. CATSPERB is required for trafficking or formation of a stable channel complex. It is involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. There are 2 isoforms produced by alternative splicing.
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hz-5538R phospho-PI3K p85/PIK3R1(Tyr368) 磷酸化磷脂酰肌醇激酶抗体
hz-5571R phospho-PIK3R1(Tyr467) 磷酸化磷脂酰肌醇激酶抗体
hz-2067R PIK3CA 磷脂酰肌醇激酶催化亚单位A抗体
hz-3593R PI3 Kinase p110 delta 磷脂酰肌醇激酶催化亚单位D抗体
hz-5572R phospho-PIK3R1(Tyr556) 磷酸化磷脂酰肌醇激酶抗体
hz-5570R phospho-PI3KCA(Tyr317) 磷酸化磷脂酰肌醇激酶催化亚单位A抗体
hz-5587R phospho-PI3K/PIK3CD(Tyr524) 磷酸化磷脂酰肌醇激酶催化亚单位D抗体
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hz-3353R Phospho-PIM1(Tyr218) 磷酸化前病毒整合位点蛋白1抗体
hz-1872R PIRH2 泛素连接酶抗体
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hz-3354R Phospho-Pin1 (Ser16) 磷酸化肽基脯氨酞顺反异构酶Pinl抗体
hz-4160R PI 3 Kinase p85 beta 磷脂酰肌醇激酶p85β抗体
hz-5582R phospho-PIK3R2(Tyr467) 磷酸化磷脂酰肌醇激酶p85β抗体
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hz-5002R PCK2 磷酸羧化酶2抗体
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hz-3964R PKA gamma 蛋白激酶Aγ抗体
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hz-3534R PLC beta 3 磷酯酶Cβ3抗体
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