英文名称 CLACP
中文名称 阿尔茨海默病淀粉样蛋白相关胶原蛋白抗体
别 名 Alzheimer disease amyloid associated protein; AMY; CLAC; CLAC P; CLAC precursor; COL25A1; COL25A1 protein; Collagen alpha 1 XXV chain; Collagen alpha 1(XXV) chain; Collagen like Alzheimer amyloid plaque component; Collagen like Alzheimer amyloid plaque component precursor; Collagen type XXV alpha 1; Collagenous Alzheimer amyloid plaque component.
说 明 书 0.1ml 0.2ml
研究领域 神经生物学 Alzheimer's
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 阿尔茨海默病淀粉样蛋白相关胶原蛋白抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
细胞定位 细胞膜 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CLACP
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
阿尔茨海默病淀粉样蛋白相关胶原蛋白抗体产品介绍 background:
Collagen proteins (products of the COL gene family) are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to form complex connective tissues. The Collagen Type XXV precursor produces the proteolytic fragment CLAC (collagenous Alzheimer amyloid plaque component), which deposits in senile plaques associated with amyloid beta peptides (Abeta) in the brains of patients with Alzheimer's disease. CLAC binds to the fibrillized form of Abeta, which disturbs the structure and function of plasma membranes.
Function:
Antibodies against senile plaque (SP) amyloid obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with approximately 50/100 kDa polypeptides in Alzheimer's diseased (AD) brains. The 9D2 antigen was identified as CLAC (collagen like Alzheimer amyloid plaque component), and its precursor as CLACP/collagen type XXV. Both secreted and membrane tethered forms of CLACP/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta amyloidogenesis and neuronal degeneration in AD.
阿尔茨海默病淀粉样蛋白相关胶原蛋白抗体
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hz-2673R C5b-9 末端补体复合物抗体
hz-3878R CQ028 多癌基因下调蛋白抗体
hz-0091R CA125/MUC16 卵巢癌抗原抗体
hz-1239R CA153/hzA/Mucin 1 乳腺癌相关抗原抗体
hz-1497R CA153/MUC1/KL-6 乳腺癌相关抗原抗体
hz-2776R CACH2/CaV1.2 L型钙通道蛋白抗体
hz-2781R CACNA1G/Cav3.1 电压依赖性钙通道Cav3.1抗体
hz-3930R CACNA1A/Cav2.1 电压依赖性钙通道Cav2.1抗体
hz-3932R CACH3/CaV1.3 L型钙通道蛋白a1亚型3抗体
hz-3933R CACH6/Cav2.3 L型钙通道蛋白a1亚型6抗体
hz-0043R DFF-40beta/CAD/CPAN Caspase 激活的脱氧核糖核酸酶抗体
hz-0813R Casein 酪蛋白抗体
hz-0030M Calcineurin A/PP-2B alpha 1 钙调磷酸酶抗体
hz-1589R Caldesmon 钙介质素抗体
hz-2082R phosphor-Caldesmon(Ser789) 磷酸化钙介质素抗体
hz-1099R Calpain 1 钙蛋白酶1抗体
hz-1599R Calpain 2 钙激活的中性蛋白酶2抗体
hz-0095R Calponin 1/COLP 钙调节蛋白-1抗体
hz-3458R Phospho-Troponin I(Ser23/24) 磷酸化钙调节蛋白-1抗体
hz-4190R SLC27A1 长链脂肪酸转运蛋白1抗体
hz-3666R Calmodulin/CaM I 钙调节素抗体(钙调蛋白/钙调素)
hz-0564R CaMK2a 钙/钙调素依赖蛋白激酶2α抗体
hz-1647R Phospho-CaMKII (Thr286) 磷酸化钙/钙调素依赖蛋白激酶2α抗体
hz-3081R phospho-CaMK2 alpha (Tyr231) 磷酸化钙/钙调素依赖蛋白激酶2α抗体
hz-5276R phospho-CaMK2 alpha (Thr305) 磷酸化钙/钙调素依赖蛋白激酶2α抗体
hz-1809R Camk1g 钙/钙调蛋白依赖蛋白激酶IG抗体
hz-0541R CaMK2 beta/CaMK2 gamma 钙/钙调素依赖蛋白激酶2b/2γ抗体
hz-4260R XPB/ERCC3 DNA损伤修复酶ERCC3蛋白抗体
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hz-1306R CAP1/PARK7 CAP1抗体
hz-1616R CAP2 环化酶相关蛋白CAP-2抗体
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