细胞分裂周期2相关蛋白激酶7抗体

英文名称    CRK7    

中文名称    细胞分裂周期2相关蛋白激酶7抗体    

别    名    CrkRS; Cdc2 related kinase arginine/serine rich; CDK12; Pksc; CDC2 related protein kinase 7; Cell division cycle 2 related protein kinase 7; CRKR; CRK7; EC 2.7.11.22; CDK12_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  信号转导  细胞周期蛋白  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 细胞分裂周期2相关蛋白激酶7抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    164kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CrkRS/CRK7    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

细胞分裂周期2相关蛋白激酶7抗体产品介绍    background:

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Function:
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.    

细胞分裂周期2相关蛋白激酶7抗体

hz-8310R COX4NB  COX4NB蛋白抗体

hz-8312R FAM82A1  微管动力调节蛋白FAM82A抗体

hz-8313R FAM46D/CT112  肿瘤/睾丸抗原112抗体

hz-8314R FAM50B  FAM50B蛋白抗体

hz-8315R FAM50C  FAM50C蛋白抗体

hz-8316R HDHD1  HDHD1蛋白抗体

hz-8317R HDHD2/IER3IP1  HDHD2蛋白抗体

hz-8318R HDHD3  HDHD3蛋白抗体

hz-8319R HDHD2B/LHPP  HDHD2B蛋白抗体

hz-8320R HEATR3  HEATR3蛋白抗体

hz-8321R HEATR6  乳腺癌增强蛋白抗体

hz-8322R Proteasome 19S S5A  26S蛋白酶调节亚型S5a抗体

hz-8324R Headpin/SERPINB13  丝氨酸蛋白酶抑制剂13抗体

hz-8325R SESN1/PA26  p53调控PA26核蛋白抗体

hz-8326R SESN2/Hi95  缺氧诱导基因95抗体

hz-8327R SLU7  SLU7蛋白抗体

hz-8328R SMEK2/PP4R3B  丝氨酸/苏氨酸蛋白磷酸酶3B抗体

hz-8329R SRXN1  硫氧还蛋白1抗体

hz-8330R STK25/YSK1  丝氨酸/苏氨酸激酶25抗体

hz-5378R PLCZ1  磷酸肌醇磷脂酶PLCZ1抗体

hz-4151R PLDL1/PLCE  磷脂酶C1样蛋白抗体

hz-8331R CPXCR1  肿瘤/睾丸抗原77抗体

hz-5379R PLTP  磷脂转移蛋白抗体

hz-8332R TM9SF4  跨膜蛋白9家族成员4抗体

hz-8333R RDH13  视黄醇脱氢酶13抗体

hz-8334R NIMP/RTN4IP1  NOGO相互作用线粒体蛋白1抗体

hz-8335R TMhz173  跨膜蛋白173抗体

hz-8336R TMhz147  跨膜蛋白147抗体

hz-8337R PANK1  泛酸激酶1抗体

hz-8338R PANK2  泛酸激酶2抗体

hz-8339R PANK3  泛酸激酶3抗体

hz-8340R PANK4  泛酸激酶4抗体

hz-8341R CPXM  羧肽酶X(M14家族1)抗体

hz-8342R CPXM2  羧肽酶X(M14家族2)抗体