脊髓灰质炎病毒受体抗体

英文名称    CD155    

中文名称    脊髓灰质炎病毒受体抗体    

别    名    Poliovirus receptor; poliovirus receptor isoform alpha; CD155; FLJ25946; HVED; Necl-5; NECL5; PVS; TAGE4; Taa1; CD155 antigen; Nectin like 5; Nectin like protein 5; Ortholog of mouse Tage4; PVR; PVR_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  神经生物学  细胞膜受体  细菌及病毒      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 脊髓灰质炎病毒受体抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    47kDa    

细胞定位    细胞膜 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CD155    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

脊髓灰质炎病毒受体抗体产品介绍    background:

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Function:
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.     

脊髓灰质炎病毒受体抗体

hz-0210P Tubulin- Beta  微管蛋白（抗原）

hz-0452P NAIF1 protein( CB12-327)  核凋亡诱导因子蛋白1(多肽)

hz-1500P cath-B/CB(Cathepsin B)  组织蛋白酶B抗原

hz-1508P cath-L/CL peptide  组织蛋白酶L抗原

hz-1134P CBFA1/RUNX2 (Runt-related Transcription Factor 2)  成骨特异性转录因子（多肽）

hz-1397P CBP(CREB-binding protein)  CREB结合蛋白抗原

hz-1421P CBX3/HP1 gamma  染色盒同源物3抗原

hz-0955P CBX5(Chromobox Homolog 5)  CBX5（多肽）

hz-1487P CC16(Clara cell protein 16) peptide  克拉拉细胞蛋白(Clara细胞分泌蛋白)抗原

hz-0562P CCR-2/5(CC chhzokine receptor 2/5)  CC趋化因子受体2/5抗原

hz-2450P CCL1/TCA3/I-309  嗜酸粒细胞趋化蛋白CCL1抗原

hz-1324P CCL5/RANTES(regulated on activation normal T cell expressed and secreted)  活化T细胞表达和分泌的调节因子抗原

hz-2475P CCL4/MIP-1 Beta(Macrophage Inflammatory Protein 1 beta)  巨噬细胞炎性蛋白1β抗原

hz-1268P MIP3 Alpha/CCL20(Macrophage inflammatory ptotein 3 alpha)  巨噬细胞炎性蛋白3α抗原

hz-2478P CCL12/MCP-5(C-C motif chhzokine 12)  单核细胞趋化蛋白5抗原

hz-2479P CCL14/HCC-1(C-C motif chhzokine 14)  嗜酸粒细胞趋化蛋白14抗原

hz-1761P ABCD-1/CCL22  嗜酸粒细胞趋化蛋白22抗原

hz-2454P MIP-3 beta/ELC/CCL19(Macrophage Inflammatory Protein 3 Beta)  巨噬细胞炎性蛋白19抗原

hz-1762P CCL26(Eotaxin 3)  嗜酸粒细胞趋化蛋白3抗原

hz-1169P CCR-1(CC chhzokine receptor 1)  细胞表面趋化因子受体1抗原

hz-1167P CCR-3(CC chhzokine receptor 3)  CC趋化因子受体3抗原

hz-1671P CCR-2A(C-C Chhzokine receptor 2A)  细胞表面趋化因子受体2A抗原

hz-1168P CCR-4(C-C chhzokine receptor 4)  细胞表面趋化因子受体4抗原

hz-1542P CCR-6/CD196 peptide  细胞表面趋化因子受体6抗原

hz-1628P CXCR6(CXC-chhzokine receptor 6) peptide  细胞表面趋化因子受体6抗原

hz-1305P CCR-7(CC chhzokine receptor 7)  CC趋化因子受体7（多肽）

hz-1502P CXCL10/IP-10  CXCL10趋化因子10/干扰素诱导蛋白10抗原

hz-0279P VEGF(Vascular endothelial growth factor)  血管内皮生长因子（多肽抗原）