整合素αM/巨噬细胞表面分子抗体

英文名称    CD11b    

中文名称    整合素αM/巨噬细胞表面分子抗体    

别    名    Antigen CD11b p170; CD11 antigen like family member B; CD11b antigen; CD49d; Cell surface glycoprotein MAC 1 alpha subunit; Cell Surface Glycoprotein MAC1 Alpha Subunit; Complement Component Receptor 3 Alpha; CR 3 alpha chain; CR3 Alpha Chain; CR3A; Integrin Alpha M; integrin alpha M complement component 3 receptor 3 subunit; Leukocyte Adhesion Receptor MO1; MAC 1; MAC1A; MGC117044; MO1A; Neutrophil Adherence Receptor; Cd11b; CD11b/CD18; F730045J24Rik; Ly-40; ITGAM; CR3A; ITAM_HUMAN;    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  神经生物学  信号转导  细胞凋亡      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 整合素αM/巨噬细胞表面分子抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    125kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CD11b    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

整合素αM/巨噬细胞表面分子抗体产品介绍    background:

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Function:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.    

整合素αM/巨噬细胞表面分子抗体

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hz-0747R OPGL/RANKL/ODF  骨保护蛋白配体抗体(破骨细胞分化因子)

hz-0019R OPN/BSP  骨桥蛋白抗体(分泌型磷蛋白1)人

hz-0026R OPN/BSP  骨桥蛋白抗体(分泌型磷蛋白1)

hz-5111R Sigma1R  衰老相关基因8蛋白抗体

hz-1181R Orexin-A  增食欲素A/欲激素A

hz-5095R OSM/Oncostatin M  抑瘤素M抗体

hz-5096R OSMR/OSMRB  抑瘤素M受体抗体

hz-1110R Osterix  成骨相关转录因子抗体

hz-5089R OXCT1  含氧酸辅酶A转移酶1抗体

hz-0807R Os05g0477200 protein  水稻白叶枯病菌Os05g0477200蛋白抗体

hz-1314R Oxytocin R  催产素受体(缩宫素受体)抗体

hz-0283R OVA/SerpinB8  鸡卵白蛋白/卵清蛋白抗体

hz-1095R CD200R/Orexin receptor  丘脑分泌素受体抗体（食欲素受体）

hz-4065R P2X2/ATP receptor  嘌呤受体P2X2抗体

hz-4249R P2RX3/ATP receptor  嘌呤受体P2X3抗体

hz-6016R RBBP5  视网膜母细胞瘤结合蛋白5抗体

hz-1483R RBBP6/P2P-R  增殖潜能相关蛋白抗体

hz-1174R P14ARF  抑癌基因p14抗体

hz-0740R CDKN2A/P16  抑癌基因p16抗体

hz-5253R phospho-CDKN2A/P16 (Ser140)  磷酸化抑癌基因p16抗体

hz-5254R phospho-CDKN2A/P16 (Ser152)  磷酸化抑癌基因p16抗体

hz-5255R phospho-CDKN2A/P16 (Ser8)  磷酸化抑癌基因p16抗体

hz-0534R CDKN2A/p19ARF  p19ARF抑癌基因抗体

hz-0741R P21/CDKN1A  p21蛋白抗体

hz-5237R phospho-CDKN1A/P21 (Thr145)  磷酸化p21蛋白抗体

hz-5238R phospho-CDKN1A/P21 (Thr57)  磷酸化p21蛋白抗体

hz-5239R phospho-CDKN1A/P21 (Ser146)  磷酸化p21蛋白抗体

hz-5274R phospho-CDKN1A/P21 (Ser130)  磷酸化p21蛋白抗体

hz-0742R CDKN1B/P27kip1  P27抗体/周期素依赖激酶抑制剂