周期素依赖性激酶4抗体

英文名称    CDK4    

中文名称    周期素依赖性激酶4抗体    

别    名    Cdk 4; CDK4 protein; Cell division kinase 4; Cell division protein kinase 4; CMM 3; CMM3; Crk3; Cyclin dependent kinase 4; Melanoma cutaneous malignant 3; MGC14458; p34 cdk4; PSK J3; CDK4_HUMAN.    

说 明 书    0.1ml  0.2ml  1ml    

研究领域    肿瘤  细胞生物  染色质和核信号  信号转导  细胞周期蛋白  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 周期素依赖性激酶4抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    34kDa    

细胞定位    细胞核 细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CDK4    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

周期素依赖性激酶4抗体产品介绍    background:

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

Function:
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.    

周期素依赖性激酶4抗体

hz-0634R AQP4  水通道蛋白-4抗体

hz-1554R AQP5  水通道蛋白5抗体

hz-2506R AQP7  水通道蛋白-7抗体

hz-4234R ABAT  γ氨基丁酸转氨酶抗体

hz-2060R AQP9  水通道蛋白-9抗体

hz-0118R Androgen receptor  雄激素受体抗体

hz-5178R Chondroitin Sulfate  硫酸软骨素抗体

hz-0943R phospho-Androgen Receptor(Ser580)  磷酸化雄激素受体抗体

hz-3004R phospho-Androgen Receptor(Ser595)  磷酸化雄激素受体抗体

hz-2903R ARHI  抑癌基因ras同源家族1抗体

hz-5191R phospho-Androgen Receptor (Ser212)  磷酸化雄激素受体抗体

hz-3847R Amphiregulin  双调蛋白（结肠直肠细胞源性生长因子）抗体

hz-2405R AKR1B1  醛糖还原酶抗体

hz-3751R ARA24  雄激素受体相关蛋白24抗体

hz-5192R phospho-Androgen Receptor(Ser660)  磷酸化雄激素受体抗体

hz-0385R ARC/Arg3.1  ARC抗体

hz-1145R ARF6  ADP核糖基化因子6抗体

hz-1477R Arfaptin 1  ADP核糖基化因子结合蛋白1抗体

hz-4230R mSin3A  同源转录调节蛋白Sin3A抗体

hz-1442R Arfaptin 2  ADP核糖基化因子结合蛋白2抗体

hz-3006R phospho-arfaptin 2(Ser260)  磷酸化ADP核糖基化因子结合蛋白2抗体

hz-4202R Arhgef2/GEF H1  Rho鸟苷酸交换因子2抗体

hz-2201R phospho-Arhgef2(Ser810)  磷酸化Rho鸟苷酸交换因子2抗体

hz-0114M Aromatase  芳香化酶抗体

hz-0114R Aromatase  芳香化酶/细胞色素P450/雌激素合成酶抗体

hz-3953R COX1/MTCO1  细胞色素c氧化酶1抗体

hz-2562R COX7A2  细胞色素c氧化酶7A2抗体

hz-3934R COX3  细胞色素C氧化酶亚基3抗体

hz-2714R COX7A2  细胞色素c氧化酶COX7A2抗体

hz-3935R COX6B  细胞色素C氧化酶亚基6B抗体

hz-3763R Activin A Receptor Type IB  激活素受体1B抗体

hz-0804R ARIP2a  激活素受体2A抗体

hz-0857R Beta-arrestin 1  β-抑制蛋白1抗体