肿瘤抑制相关蛋白PHEMX抗体

英文名称    ART1    

中文名称    肿瘤抑制相关蛋白PHEMX抗体    

别    名    ART 1; ART1; FLJ17158; FLJ97586; MGC22455; Pan hematopoietic expression; PHEMX; PHMX; tetraspanin 32; Tetraspanin; tetraspanin32; TSPAN32; TSSC6; Tumor suppressing STF cDNA 6; Tumor suppressing subchromosomal transferable fragment cDNA 6; Tumor suppressing subtransferable candidate 6.    

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 肿瘤抑制相关蛋白PHEMX抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    35kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PHEMX/ART1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

肿瘤抑制相关蛋白PHEMX抗体产品介绍    background:

Phemx is a member of the tetraspanin (TM4SF) family of proteins that may be involved in transmembrane signal transduction, regulation of cell proliferation, differentiation and motility. Phemx is a multi-pass membrane protein containing intracellular N- and C-terminal domains, four transmembrane domains and two extracellular loops. It is ubiquitously expressed from early embryogenesis through adulthood. Phemx exhibits predominant expression in hematopoietic tissues suggesting a role in hematopoietic-cell function. In association with the Integrin αIIb/Integrin β3 complex, Phemx functions to stabilize arterial thrombi in platelets and regulate “outside-in” signaling. This interaction may be important in the process of wound healing. The gene encoding Phemx is located in an important tumor-suppressor gene region that has been associated with Beckwith-Wiedemann syndrome as well as a variety of cancers.

Function:
PHEMX belongs to the conserved tetraspanin family of integral membrane proteins, which are thought to form multiprotein networks in the cell membrane in association with multiple protein partners. Tetraspanins have functional roles in cell motility, membrane fusion, proliferation, and adaptive immunity. This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. PHEMX may play a role in malignancies and disease that involve this region as well as hematopoietic cell function. There are 5 isoforms produced by alternative splicing.    

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