原钙粘附蛋白8抗体

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英文名称  Anti-PCDH8 

中文名称  原钙粘附蛋白8抗体

别    名  Arcadlin; PAPC; PCDH 8; Protocadherin 8; Protocadherin8; PCDH8_HUMAN. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Pig, Cow, Rabbit, Goose, Sheep, Chimpanzee

原钙粘附蛋白8抗体的多样性：

抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。

因为抗体具有与抗原决定簇相对应的结合部位（抗原结合簇），所以抗体与抗原的结合具有特异性。另一方面，抗体本身是一种蛋白质，具有本身的氨基酸组成、排列和立体结构，对异种动物来说，它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性，它们表现出不同的血清学类型。

原钙粘附蛋白8抗体的相关产品:

Rabbit Anti-Guinea pig IgG/PE  PE标记的兔抗豚鼠IgG 0.1ml

Rabbit Anti-Guinea pig IgG/PE-Cy3  PE-Cy3标记的兔抗豚鼠IgG 0.1ml

Rabbit Anti-Guinea pig IgG/PE-CY5  PE-CY5标记的兔抗豚鼠IgG 0.1ml

Rabbit Anti-Guinea pig IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗豚鼠IgG 0.1ml

产品类型  一抗    

研究领域  神经生物学 信号转导 细胞粘附分子 细胞骨架 细胞外基质 细胞膜蛋白  

蛋白分子量  predicted molecular weight: 110kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PCDH8 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDH8 (protocadherin-8), also known as Arcadlin or PAPC, is a 1,070 amino acid single-pass type I membrane protein that contains six cadherin domains and belongs to the protocadherin family. Localized to the cell membrane and expressed specifically in fetal and adult brain, PCDH8 is thought to play a role in cell adhesion events in the central nervous system (CNS). PCDH8 is inactivated or silenced in breast cancer, suggesting a possible role in tumor suppression. Two isoforms of PCDH8 that differ in their cytoplasmic tails are expressed due to alternative splicing events.

Function : PCDH8 (Protocadherin 8) belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. It is thought to function in cell-adhesion in a calcium-dependent manner. It is predominantly expressed in brain, localizing to synaptic junctions.

Subunit : The N-terminal extracellular domain forms homophilic interactions; these interactions activate p38 MAPK via TAOK2 and trigger endocytosis (By similarity). Interacts with CDH2; this interaction may lead to CDH2 cointernalization (By similarity). Interacts with CDH11 (By similarity). 原钙粘附蛋白8抗体Interacts with TAOK2 (By similarity). 

Subcellular Location : Cell Membrane. Single-pass type I membrane protein.

Similarity : Contains 6 cadherin domains. 

Database links : UniProtKB/Swiss-Prot: O95206.2