表观抑制因子Polycomb家族成员PCGFl蛋白抗体

公司表观抑制因子Polycomb家族成员PCGFl蛋白抗体具有高纯度、高效价、高特异性的特点，仅用于科学研究，不可用于临床诊断及药物治疗，可以应用于多种实验。CST、Santa抗体品牌。

英文名称  Anti-PCGF1 

中文名称  表观抑制因子Polycomb家族成员PCGFl蛋白抗体 

别    名  PCGF1; Nervous system Polycomb-1; NSPc1; Polycomb group RING finger protein 1; RING finger protein 68; PCGF1_HUMAN; RNF68. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg
表观抑制因子Polycomb家族成员PCGFl蛋白抗体的相关产品:

RAMP/CDT2  维甲酸调节核基质相关蛋白 0.2ml

RAMP1  受体活性修饰蛋白1抗体 0.2ml

Ran/ARA24  雄激素受体相关蛋白24抗体 0.2ml

RanBP1  RAN结合蛋白1抗体 0.2ml

表观抑制因子Polycomb家族成员PCGFl蛋白抗体抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit 

产品类型  一抗    

研究领域  细胞生物 免疫学 细胞周期蛋白 细胞分化  

蛋白分子量  predicted molecular weight: 30kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human PCGF1 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 PCGF1 is a component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. It represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). PCGF1 als promotes cell cycle progression and also enhances cell proliferation, thus it may have a positive role in tumor cell growth.

Function : Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 

Subunit : Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, RING1 and RNF2/RING2. Specifically interacts with BCOR, RING1 and RNF2/RING2. Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8.

Subcellular Location : Nucleus.

表观抑制因子Polycomb家族成员PCGFl蛋白抗体Tissue Specificity : Ubiquitous.

Similarity : Contains 1 RING-type zinc finger.

Database links : UniProtKB/Swiss-Prot: Q9BSM1.2

公司提供表观抑制因子Polycomb家族成员PCGFl蛋白抗体价格绝对优势，欢迎新老客户来电垂询我公司优质抗体表观抑制因子Polycomb家族成员PCGFl蛋白抗体说明书及报价等。