Activin A is a TGF-β family member that exhibits a wide range of
biological activities, including regulation of cellular proliferation
and differentiation, and promotion of neuronal survival. Elevated
levels of Activin A in human colorectal tumors and in postmenopausal
women have been implicated in colorectal and breast cancers,
respectively. The biological activities of Activin A can be neutralized
by inhibins and by the diffusible TGF-β antagonist, follistatin.
Activin A binds to the two forms of activin receptor type I (Act RI-A
and Act RI-B) and two forms of activin receptor type II (Act RII-A and
Act RII-B). Activins are homodimers or heterodimers of different β
subunits. They are produced as precursor proteins with an amino
terminal propeptide that is cleaved to release the C-terminal bioactive
ligand. Recombinant Human/Murine/Rat Activin A is a 26.0 kDa
disulfide-linked homodimer of two βA chains, each containing 116 amino
acid residues.
Manufactured using all Animal-Free reagents.
Source: E.coli
Synonyms: Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein, Erythroid Differentiation Factor (EDF)
AA Sequence (monomer): GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Purity: ≥ 97% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
This product has been tested against the WHO standard. International Unit information can be found here.
Calculated Molecular Weight: 26 kDa
Accession Number: P08476
Gene ID: 3624
Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)
Note:
1mg will be provided as 2x500μg.
crossreactivity:
Chicken, Dog, Frog, Human, Human + Mouse, Mouse, Rat
Animal-Free Recombinant Human/Murine/Rat Activin A (E.coli derived)信息由上海远慕生物科技有限公司为您提供,如您想了解更多关于Animal-Free Recombinant Human/Murine/Rat Activin A (E.coli derived)报价、型号、参数等信息,欢迎来电或留言咨询。除供应Animal-Free Recombinant Human/Murine/Rat Activin A (E.coli derived)外,上海远慕生物科技有限公司还可为您提供维生素B1测试盒 可见分光光度法、共价结合型果胶(CSP)含量测试盒 可见分光光度法、二磷酸核酮糖羧化酶(Rubisco)测试盒 微量法等产品,公司有专业的客户服务团队,是您值得信赖的合作伙伴。