BMP-13 is expressed in hypertrophic chondrocytes during embryonic
development of long bones. Continued postnatal expression of BMP-13 in
articular cartilage suggests that it plays a regulatory role in the
growth and maintenance of articular cartilage. Adenovirus-mediated
BMP-13 gene transfer to rabbit bone marrow stem cells have been reported
to augment periosteal repair of osteochondral defects. The functional
form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120
amino-acid polypeptide chains. This 27.5 kDa protein is obtained by
proteolytic processing of a biologically inactive precursor protein of
97.7kDa. Recombinant Human BMP-13/CDMP-2 is a 27.0 kDa homodimeric
disulfide-linked protein consisting of two 120 amino acid polypeptide
chains.
Manufactured using all Animal-Free reagents.
Source: E.coli
Synonyms: Bone Morphogenetic Protein-13, GDF-6, Cartilage-Derived Morphogenetic Protein-2 (CDMP-2)
AA Sequence (monomer): TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL
EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA GNNVVYKQYE DMVVESCGCR
Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
Calculated Molecular Weight: 27 kDa
Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2.0-3.0 µg/ml.
Accession Number: Q6KF10
Gene ID: 392255
Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)
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