GDF-5 is expressed in long bones during embryonic development and
postnatally in articular cartilage. Mutations in the GDF-5 gene have
been implicated in Hunter-Thompson type dwarfism and in
Grebe Syndrome, which is characterized by short stature, extra digits,
and short and deformed extremities. The mature and functional form of
GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers)
linked by a single disulfide bond. Each GDF-5 monomer is expressed as
the C-terminal part of a precursor polypeptide, which also contains a 27
amino acid signal peptide and a 354 amino acid propeptide. This
precursor undergoes intracellular dimerization, and upon secretion it is
processed by a furin-type protease. Recombinant Human GDF-5 is a 27.0
kDa homodimeric disulfide-linked protein consisting of two 120 amino
acid polypeptide chains.
Source: E.coli
Synonyms: Growth/Differentiation Factor-5, BMP-14, Cartilage-Derived Morphogenetic Protein-1 (CDMP-1)
AA Sequence (monomer): APLATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL
EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1.0-2.0 µg/ml.
Calculated Molecular Weight: 27 kDa
Accession Number: P43026
Gene ID: 8200
Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
Cross Reactivity Cited in References:
Human, Mouse, Sheep
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