Sox2 belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and the determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development, including FGF-4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4 into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology, gene expression, and in their capacity to form teratomas in immune-deficient mice. Recombinant Human Sox2 is a 34.3 kDa protein containing 317 amino acid residues.
Source: E.coli
Synonyms: Sex determining Reqion Y (CRY)-box 2
AA Sequence: MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM GSVVKSEASS SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS GPVPGTAING TLPLSHM
Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Not available.
Calculated Molecular Weight: 34.3 kDa
Accession Number: P48431
Gene ID: 6657
Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
Recombinant Human Sox2信息由上海远慕生物科技有限公司为您提供,如您想了解更多关于Recombinant Human Sox2报价、型号、参数等信息,欢迎来电或留言咨询。除供应Recombinant Human Sox2外,上海远慕生物科技有限公司还可为您提供大鼠14-3-3 蛋白 beta/alpha(YWHAB)ELISA试剂盒、大鼠15-epi-氧脂素 A4(15-epi-LXA4)ELISA试剂盒、大鼠210kDa核孔蛋白(NUP210)ELISA试剂盒等产品,公司有专业的客户服务团队,是您值得信赖的合作伙伴。