p53正向细胞凋亡调控因子抗体
产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
p53正向细胞凋亡调控因子抗体产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 (石蜡切片需做抗原修复)
p53正向细胞凋亡调控因子抗体产品介绍
nbsp; PUMA is an essential mediator of p53-dependent and p53-independent apoptosis. It is localized in the mitochondria and induces cytochrome c release and activates the rapid induction of programmed cell death. There are two isoforms, alpha and beta.
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b (1). PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Also known as: bcl-2 binding component 3; BBC 3; BBC3; BCL 2 binding component 3; BCL2 binding component 3; JFY 1; JFY1; p53 up regulated modulator of apoptosis; p53 Upregulated Modulator of Apoptosis; PUMA alpha; PUMA/JFY1
xy-9467R DVL3DVL3蛋白抗体
xy-1359R DNA PKcsDNA依赖蛋白激酶催化亚基抗体
p53正向细胞凋亡调控因子抗体
xy-1361R DDIT3GADD153抗体
xy-8555R Desmuslin中间丝蛋白β-synemin抗体
xy-9669R DENND4CMAP激酶激活死亡域蛋白4C抗体
xy-9926R Desmocollin 4桥粒糖蛋白4抗体
xy-11343R Dynamin 3酶动力蛋白3抗体
xy-7000R Delta Cateninδ连环蛋白/δ连环素/δ链接素(δ-catenin)抗体
xy-11066R DOK6胞浆接头蛋白Dok6抗体
xy-8587R DOK5胞浆接头蛋白Dok5抗体
xy-9394R DCAF12睾丸癌中心体相关蛋白抗体
xy-9395R DCAF13DCAF13蛋白抗体
xy-6999R DCHS1原钙粘蛋白16抗体
xy-6998R ERR-alpha雌激素受体相关蛋白α抗体
xy-8291R DPY19L2DPY19L2蛋白抗体
xy-8288R DPYD二氢嘧啶脱氢酶抗体
xy-8289R DPY19L1短粗矮胖19蛋白样1抗体
xy-8292R DPY19L4DPY19L4蛋白抗体
xy-8294R DPP9二肽基肽酶9抗体
xy-8295R DPP8二肽基肽酶8抗体
xy-12037R DRD4多巴胺受体D4抗体
xy-8293R DQX1DQX1蛋白抗体
xy-7117R DDX5三磷酸腺苷依赖解旋酶ddx5抗体
xy-8005R phospho-DDX5 (Tyr593)磷酸化三磷酸腺苷依赖解旋酶ddx5抗体
xy-11862R DYX2/KIAA0319阅读障碍相关蛋白DLX2抗体
xy-10046R Dystrobrevin alpha肌营养蛋白α抗体
xy-10064R CD299CD299抗体
xy-11546R DUSP6双特异性蛋白磷酸酶6/丝裂原活化蛋白激酶磷酸酶3抗体
xy-11547R Dab1磷脂蛋白受体Dab1抗体
xy-11548R Phospho-Dab1 (Tyr198) 磷酸化磷脂蛋白受体Dab1抗体
xy-11550R DLX2同源转录因子DLX2抗体
xy-2983R Desmocollin 2桥粒糖蛋白2/桥粒糖蛋白3抗体
xy-6307R Desmocollin 1桥粒糖蛋白1抗体
xy-6630R Destrin 19肌动蛋白解聚因子19抗体
xy-6929R DCTN1动力蛋白激活蛋白1抗体
xy-6725R Desmoglein 1桥粒芯糖蛋白1
xy-5801R DLC1胞浆动力蛋白轻链1抗体
xy-11827R DRGX背根神经节同源蛋白DRGX抗体
xy-5909R DeltaDDeltaD抗体