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Analysis of ibuprofen in serum by capillary electrophoresis
Journal of Chromatography B: Biomedical Sciences and Applications, Volume 683, Issue 1, Pages 115-118 (9 August 1996)
Z. K. Shihabi and M. E. Hinsdale
683-115

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A Rapid and Simultaneous Determination of Several Analgesic Antiinflammatory Agents by Capillary Zone Electrophoresis.

Original Articles

Therapeutic Drug Monitoring. 25(5):574-580, October 2003.
Makino, Kazutaka; Yano, Takahisa; Maiguma, Takayoshi; Teshima, Daisuke; Sendo, Toshiaki; Itoh, Yoshinori; Oishi, Ryozo
Abstract:
Summary: A rapid and simultaneous determination of several analgesic antiinflammatory agents-ibuprofen, acetaminophen, indomethacin, and salicylic acid-in human serum was developed by using capillary zone electrophoresis (CZE) coupled with diode-array ultraviolet detection. After precipitation of serum protein with acetonitrile containing 3-isobutyl-1-methylxanthine as the internal standard, an aliquot of deproteinized samples was applied directly to the CZE system. It enabled us to measure all of these four agents within 6 min, and there were no peaks interfering with the assay of these agents or 3-isobutyl-1-methylxanthine. Both the separation and quantification of these agents in human serum were reproducible after repeated analysis within a day or day-to-day analysis. In addition, there was a good correlation for each drug (r = 0.997-0.999) between the values in serum determined by CZE analysis and those measured either by high-performance liquid chromatography with ultraviolet detection (ibuprofen and indomethacin) or by fluorescence polarization immunoassay (acetaminophen and salicylic acid). Therefore, the present CZE analysis could provide a simple, rapid, and efficient method for the identification as well as monitoring of analgesic antiinflammatory agents, particularly in serum of patients suffering from intoxication by overdosage of these agents.