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 回复wds408发表于:2007/4/9 16:19:00悬赏金额:50积分 状态:已解决
1 Binding of nonsteroidal anti-inflammatory agents to proteins—I. Ibuprofen-serum albumin interaction

John B. Whitlam, Michael J. Crooks, Kenneth F. Brown and Peter Veng Pedrrsen

Department of Pharmacy, University of Sydney, Sydney, N.S.W. 2006, Australia

Received 2 March 1978;  accepted 20 June 1978. ; Available online 15 November 2002
Biochemical Pharmacology
Volume 28, Issue 5 , 1 March 1979, Pages 675-678

2 Enhanced albumin protein separations and protein—drug binding constant measurements using anti-inflammatory drugs as run buffer additives in affinity capillary electrophoresis

Peng Sun, Alexandra Hoops and Richard A. Hartwick

Department of Chemistry, State University of New York at Binghamton Binghamton, NY 13902, USA

Received 14 June 1994;  revised 16 August 1994.  Available online 26 February 2002
Journal of Chromatography B: Biomedical Sciences and Applications
Volume 661, Issue 2 , 18 November 1994, Pages 335-340

需要上面两篇文献
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谢谢!~
taijiandong 回复于:2007/4/11 14:28:00
这个是第二篇文献。

由于我的威望小于50,所以上传的附件还需要验证,所以我也上传到了网络硬盘上面。
第2篇文献


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 回复  1# mitchie  回复于:2007/4/11 9:30:00
我只能查到第二篇的摘要
Enhanced albumin protein separations and protein-drug binding constant measurements using anti-inflammatory drugs as run buffer additives in affinity capillary electrophoresis.Sun P, Hoops A, Hartwick RA.
Department of Chemistry, State University of New York at Binghamton 13902.

An affinity capillary electrophoresis (ACE) method for improving albumin protein separations has been developed. Separation efficiencies for bovine serum albumin (BSA) and human serum albumin (HSA) are dramatically improved by using anti-inflammatory compounds as run buffer additives. The anti-inflammatory drugs used as biospecific ligands to improve the protein separation include ibuprofen (IB), flurbiprofen (FL), and ketoprofen (KE). The binding constants of proteins (BSA and HSA) for the anti-inflammatory ligands (FL and IB) are estimated by ACE and compared to literature values.
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