回复zzz23010402发表于:2020/7/31 13:40:13悬赏金额:
11积分 状态:
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USP溶出数据库里度他雄胺软胶囊的溶出方法如下:
Tier I: Dissolution Medium: 0.1 N HCI with 2% (w/v) sodium dodecyl sulfate (SDS) (900 mL)
Tier II: Dissolution Medium: 0.1 N HCI with pepsin (as per USP) (450 mL) for the first 25 minutes, followed by addition of 0.1 N HCI with SDS (4% w/v) (450 mL) for the remainder of the dissolution test.
请问是怎么操作的?是分两种情况吗,假如第一种方法测定不了,用第二种吗?还是可以分开用?