回复happyjyl发表于:2008/6/17 16:45:09悬赏金额:
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标题:Method development and validation for the HPLC assay (potency and related substances) for 20 mg paroxetine tablets
作者:John Lambropoulos, George A. Spanos and Nick V. Lazaridis
杂志:Journal of Pharmaceutical and Biomedical Analysis
Volume 19, Issue 5, April 1999, Pages 793-802
摘要:A reversed phase high performance liquid chromatographic (HPLC) method was developed and validated for use as a stability indicating assay (potency and related substances) of paroxetine in paroxetine hydrochloride 20 mg tablets. Assay samples were extracted at a paroxetine concentration of 0.4 mg ml−1 utilizing mobile phase as the extraction solvent. The chromatographic conditions employed a C18 column (Inertsil, 5 μm, 15 cm×4.6 mm), isocratic elution with 10 mM 1-decane sulfonic acid sodium salt containing 10 mM sodium phosphate monobasic (pH 3.0)–ACN (60:40, v/v) and ultraviolet (UV) detection at 235 nm.
网址:http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TGX-3VVTHD4-G&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=8147a4e72cb61be808de35f935fdc0f6
非常感谢!