这是一篇发表在Chem. Rev(IF>28)上的综述
作者:Kenneth B. Tomer
Contents
I. Introduction 297
II. Mass Spectrometry 298
A. Ionization Modes 298
1. ESI 298
2. Particle Beam Interface 298
B. Mass Analyzers 299
1. Duty Cycle 299
2. Time-Of-Flight-MS 299
3. Ion Traps and FT-MS 300
III. Separations 300
A. HP
$$lc 300
1. Miniaturization 300
2. High-Speed
$$lc Separations 302
B. Capillary Electrophoresis 303
1. Interfaces 303
2. CE-MS Sensitivity 305
3. Micellar Electrokinetic Chromatography and Sieving CE Combined with MS 307
4. CE-MS Outlook 307
C. Capillary Electrochromatography-MS 307
1. Interface Design 308
2. Applications 309
3. Comparisons of CEC-MS with HP
$$lc-MS and CE-MS 309
D. Multidimensional Chromatography with MS 310
E. Microfabricated Microfluidic Devices (Microchips) 312
F.
$$lc Combined with MALDI/MS 315
G. Affinity Separations and Mass Spectrometry 317
1. Affinity Chromatography-MS 317
2. Biomolecular Interaction Analysis (BIA)-MS 320
3. Affinity Capillary Electrophoresis-MS 321
H. Supercritical Fluid Chromatography-mass Spectrometry 321
1. Interface Design 321
2. Applications 322
I. Gas Chromatography-Mass Spectrometry 322
IV. Concluding Remarks 323
V. Acknowledgments 324
VI. References 324
Separations Combined with Mass Spectrometry